Darwin Nunez, Liverpool forward, got into a fight with fans after Uruguay lost to Colombia, earning him a five-game international ban.
Nunez, 25, was found aggressively addressing Colombian fans in the grandstand following the conclusion of the Copa America semifinal in July.
Additionally, the players were fined £15,145 ($20,000).
Conmebol, the organization that oversees football in South America, said in a statement on Wednesday that 11 players had been fined and five players, including Nunez, had been suspended for their roles in the brawl.
Tottenham midfielder Rodrigo Bentancur, 27, has received a four-game ban.
Napoli defender Mathias Olivera, 26, Barcelona defender Ronald Araujo, 25, and Atletico Madrid defender Jose Maria Gimenez, 29, have all received three-game bans.
Conmebol had opened an investigation into the “unacceptable” scenes. The incident broke out in a section of the stadium where many family members of the Uruguay players were seated.
Nunez had climbed railings and made his way into the crowded stands.
“There was no police and we had to defend our families,” said Gimenez at the time.
“This is the fault of two or three people who had a few too many drinks and don’t know how to drink.”
The bans are a blow to Uruguay boss Marcelo Bielsa, the former Leeds United manager, whose side are involved in several qualifying matches in September and October for the 2026 World Cup.
Uruguay face Paraguay in Montevideo in a qualifying match on 6 September.